Journal Reviews

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | Retina / Uvea / Vitreous | chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity

There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...